ZYDELIG(idelalisib) Patient Assistance Program
Don’t let the high cost of brand specialty oral oncology therapy disrupt your treatment. We help eligible patients access Zydelig (idelalisib) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
HIPAA Compliant
BBB Accredited
Secure Website
Key Takeaways:
- Zydelig (idelalisib) is FDA-approved in combination with rituximab for relapsed chronic lymphocytic leukemia (CLL) when rituximab alone is appropriate due to comorbidities, and as monotherapy for relapsed follicular B-cell non-Hodgkin lymphoma (FL) and relapsed small lymphocytic lymphoma (SLL) in patients who have received at least two prior systemic therapies.
- Without assistance, Zydelig costs commonly run approximately $13,500–$15,500 per 30-day supply.
- Through AffordMyPrescriptions, qualifying patients can access Zydelig for a flat $69.95 per month — our advocacy team manages the entire enrollment, refills, and renewal process.
- There is no generic Zydelig in the U.S. as of 2026. Other PI3K inhibitors and BTK inhibitors are available for CLL/FL/SLL — ibrutinib (Imbruvica), acalabrutinib (Calquence), zanubrutinib (Brukinsa), venetoclax-based combinations, and others. The choice of therapy depends on disease, prior treatment, comorbidities, and tolerability.
What is Zydelig Prescription Assistance Program?
The Zydelig Prescription Assistance Program is a manufacturer-sponsored initiative that provides Zydelig at little or no medication cost to qualifying patients based on income and insurance status. The program is designed for relapsed CLL, FL, and SLL patients who are uninsured or underinsured, as well as Medicare Part D beneficiaries.
Navigating the program on your own means dealing with eligibility verification, oncology coordination, REMS compliance, prior-authorization documentation, and renewal deadlines.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your enrollment, from initial application through ongoing refill coordination and re-certification.
Pharmacy Price Comparison
- Without assistance, Zydelig costs roughly $13,500–$15,500/month. A Patient Assistance Program is the meaningful path forward — if you qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens | ~$15,000 | Save ~$14,930/mo |
| CVS Pharmacy | ~$15,500 | Save ~$15,430/mo |
| Walmart | ~$13,800 | Save ~$13,730/mo |
| Costco | ~$13,600 | Save ~$13,530/mo |
| GoodRx Best Price | ~$13,500 | Save ~$13,430/mo |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. Afford My Prescriptions Advocacy Service bypasses retail pricing by using drug manufacturer programs to secure your medication for you—independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Zydelig Prescription Program?
The Patient Assistance Program is free to apply for and provides Zydelig at no medication cost if approved. Our $69.95/month service covers full advocacy.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Zydelig:
Limitations of Coupons
Prices fluctuate — savings aren’t guaranteed month-to-month
Copay accumulators may prevent savings from counting toward your deductible
Coupon cards expire and require constant renewal
Still $13,500–$15,500 per month even with the best discount
Cannot be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
Medication supplied directly through the assistance program
We manage all paperwork, refills, and annual renewals
Medicare Part D patients accepted
If denied, we explore alternative savings paths on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Zydelig assistance.
- You are a U.S. citizen or legal resident
- You Have A Valid Abraxane Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured Or Underinsured And Cannot Afford Your Medication
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Zydelig:
Zydelig (idelalisib) is a once-twice-daily oral selective inhibitor of phosphoinositide 3-kinase delta (PI3Kδ) used to treat relapsed chronic lymphocytic leukemia (in combination with rituximab) and relapsed follicular lymphoma and small lymphocytic lymphoma (as monotherapy after at least two prior therapies).
How It Works:
B-cell malignancies (CLL, FL, SLL) depend on signaling pathways downstream of the B-cell receptor (BCR) for cell growth and survival. The PI3Kδ isoform is highly expressed in B-cells and is a critical node in BCR signaling — blocking PI3Kδ disrupts the survival signals that drive these cancers.
Idelalisib selectively inhibits PI3Kδ, blocking activation of downstream effectors (Akt, mTOR) that promote B-cell proliferation, migration, and survival. The result is reduced lymphoma cell growth and induction of apoptosis. Idelalisib is selective for PI3Kδ over the other PI3K isoforms (α, β, γ), which limits some off-target effects but does not eliminate immune-mediated toxicities.
Form and Use:
Zydelig is taken as one 150 mg tablet by mouth twice daily, with or without food. For CLL, it is given in combination with rituximab IV. For FL/SLL, it is given as monotherapy after at least two prior systemic therapies. Treatment continues until disease progression or unacceptable toxicity.
Generic Availability:
There is no generic Zydelig in the U.S. as of 2026. Other treatment options for relapsed CLL/FL/SLL include BTK inhibitors (ibrutinib/Imbruvica, acalabrutinib/Calquence, zanubrutinib/Brukinsa), venetoclax-based combinations (Venclexta), CD20-targeted antibodies (rituximab, obinutuzumab), and other PI3K inhibitors (duvelisib/Copiktra). Choice depends on disease subtype, prior therapy, and comorbidities.
Warnings:
Zydelig carries multiple boxed warnings including hepatotoxicity (severe and fatal — monitor ALT/AST), severe diarrhea/colitis, pneumonitis (severe — including fatal), infections (including serious or fatal — Pneumocystis jirovecii prophylaxis recommended; CMV monitoring), and intestinal perforation. Other warnings include severe cutaneous reactions, anaphylaxis, neutropenia, and embryo-fetal toxicity.
FAQ (Frequently Asked Questions)
How Much Does Zydelig Cost Without Insurance?+
Zydelig costs approximately $13,500–$15,500 per 30-day supply. Through AffordMyPrescriptions, qualifying patients receive Zydelig at no medication cost — our $69.95 monthly fee covers full advocacy and program management.
How Is Zydelig Different From Ibrutinib (Imbruvica)?+
Both target B-cell receptor signaling but at different points. Ibrutinib (and the newer acalabrutinib, zanubrutinib) inhibits Bruton’s tyrosine kinase (BTK). Zydelig inhibits PI3Kδ. BTK inhibitors are now generally preferred for first-line and second-line CLL therapy due to better tolerability profiles. Zydelig has more frequent and severe immune-mediated toxicities (colitis, pneumonitis, hepatitis), so its use has decreased substantially in CLL.
What Is Pneumocystis Prophylaxis And Why Do I Need It?+
Zydelig increases the risk of opportunistic infections, including Pneumocystis jirovecii pneumonia (PJP). To prevent PJP, prophylactic trimethoprim-sulfamethoxazole (Bactrim) is recommended throughout Zydelig therapy and for at least 2–6 months after stopping. CMV reactivation should also be monitored.
What Side Effects Should I Watch For?+
Important side effects include diarrhea (sometimes severe and requiring hospitalization), liver enzyme elevations (LFTs are monitored regularly), pneumonitis (any cough or shortness of breath should be evaluated), infections (any fever should be evaluated promptly), and neutropenia. Tell your oncologist promptly about any new GI, respiratory, liver, or infectious symptoms.
What if my application is denied?
If denied, we explore alternatives — switching to a BTK inhibitor (Imbruvica, Calquence, Brukinsa) or venetoclax-based therapy (each with its own PAP), the manufacturer’s copay program for commercially insured patients, or independent foundations such as the Leukemia & Lymphoma Society. If we cannot find a path, you won’t be charged our service fee.
How Long Will I Be On Zydelig?+
Treatment continues as long as the disease is responding and the medication is well tolerated. Most patients remain on Zydelig until disease progression or unacceptable toxicity. Some patients tolerate Zydelig for years; others discontinue earlier due to side effects.
Take Control of Your Medication Costs
If you are struggling with the high cost of Zydelig, our team may be able to help you access assistance programs designed to make brand specialty oral oncology therapy affordable. Check your eligibility today.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.