ZERBAXA (ceftolozane/tazobactam) Patient Assistance Program
Don’t let the high cost of brand specialty resistant Pseudomonas/gram-negative therapy disrupt your treatment. We help eligible patients access Zerbaxa (ceftolozane/tazobactam) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey.
- Annual Re-certification And Refills Management
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Key Takeaways:
- Zerbaxa (ceftolozane/tazobactam) is FDA-approved for hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia (HABP/VABP), complicated UTI (cUTI), and complicated intra-abdominal infection (cIAI, with metronidazole) in adults. Especially active against drug-resistant Pseudomonas aeruginosa.
- Without assistance, Zerbaxa costs commonly run approximately $400–$700 per dose; typical course costs $8,000–$20,000+.
- Through AffordMyPrescriptions, qualifying patients can access Zerbaxa for a flat $69.95 per month.
- Other novel β-lactam/inhibitor combinations: ceftazidime/avibactam (Avycaz), meropenem/vaborbactam (Vabomere), imipenem/cilastatin/relebactam (Recarbrio), cefiderocol (Fetroja), eravacycline (Xerava). Choice depends on resistance pattern.
What Is Zerbaxa Prescription Assistance Program?
Zerbaxa PAP for MDR gram-negative infections.
Eligibility, ID/hospital coordination.
AffordMyPrescriptions eliminates that burden. $69.95/month advocacy.
Pharmacy Price Comparison
- Zerbaxa $400–$700/dose. PAP can help:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Hospital pharmacy | ~$650/dose | Save substantially |
| Inpatient billing | ~$700/dose | Save substantially |
| Specialty Pharmacy | ~$500/dose | Save substantially |
| Specialty Pharmacy | ~$420/dose | Save substantially |
Costco | ~$410/dose | Save substantially |
*Just a heads-up — retail prices are estimates based on public data and vary by pharmacy. AffordMyPrescriptions Advocacy Service bypasses this by using drug manufacturer programs to secure your medication directly at no cost or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Zerbaxa Prescription Program?
PAP at no cost. Typically inpatient — hospital billing coordination important.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Zerbaxa:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Coupon cards expire and require constant renewal
Still $400–$700 per dose per month even with the best discount
- Can’t be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
- Medication supplied directly through the assistance program
- We manage all paperwork, refills, and annual renewals
- If denied, we explore alternative savings on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Zerbaxa assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Zerbaxa Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured Or Underinsured And Cannot Afford Your Medication
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Not sure if you qualify? Our pre-qualification check is completely free. If we can’t help, you won’t be charged.
Understanding Zerbaxa:
Zerbaxa combines ceftolozane (a novel cephalosporin with enhanced activity against Pseudomonas aeruginosa) and tazobactam (β-lactamase inhibitor). Particularly useful for drug-resistant Pseudomonas infections — including multidrug-resistant strains with AmpC overexpression or efflux mechanisms.
How Zerbaxa Works:
Pseudomonas aeruginosa has multiple resistance mechanisms — chromosomal AmpC β-lactamase, efflux pumps, porin loss, target modification. Multi-drug-resistant Pseudomonas is a major nosocomial pathogen with limited options.
Ceftolozane is structurally similar to ceftazidime but with enhanced affinity for Pseudomonas PBP3 and resistance to AmpC β-lactamase activity. Tazobactam inhibits ESBL β-lactamases. The combination has improved activity against MDR Pseudomonas vs. traditional anti-pseudomonal β-lactams. Not active against carbapenem-resistant Enterobacterales with KPC carbapenemases (use Avycaz, Recarbrio, or Vabomere for those).
Form and use:
Zerbaxa given as IV infusion over 1 hour every 8 hours. Higher dose (3 g — 2 g ceftolozane / 1 g tazobactam) for HABP/VABP; standard dose (1.5 g — 1 g/0.5 g) for cUTI/cIAI. Renal dose adjustment for CrCl <50.
Generic availability:
No generic. Other agents for MDR Pseudomonas: traditional anti-pseudomonal β-lactams (cefepime, piperacillin/tazobactam, meropenem, imipenem — if susceptible), aminoglycosides (gentamicin, tobramycin, amikacin), fluoroquinolones (ciprofloxacin, levofloxacin — if susceptible), polymyxins (colistin, polymyxin B). For carbapenem-resistant strains: Avycaz, Recarbrio, Vabomere, Fetroja depending on resistance mechanism.
Warnings:
Zerbaxa carries warnings for hypersensitivity reactions (severe, including anaphylaxis — caution in β-lactam allergy), reduced clinical response in patients with renal impairment (creatinine clearance changes during therapy), C. difficile diarrhea, drug-resistant bacteria emergence with inappropriate use.
FAQ (Frequently Asked Questions)
Cost?
$400–$700/dose. Course $8,000–$20,000+. Hospital billing typically includes.
When is Zerbaxa used?
Drug-resistant gram-negative infections — especially MDR Pseudomonas aeruginosa. Inpatient use coordinated by ID specialist with culture/susceptibility data. Not for CRE (use Avycaz/Recarbrio/Vabomere). Not first-line for susceptible infections (use older β-lactams).
MDR Pseudomonas?
Pseudomonas with multiple resistance mechanisms — common in ICU, immunocompromised, prolonged hospitalization, prior antibiotic exposure. Zerbaxa often the agent of choice when standard anti-pseudomonal β-lactams fail. ID consultation essential.
Carbapenem-resistant?
Zerbaxa NOT active against most carbapenem-resistant Enterobacterales (KPC, OXA-48, metallo-β-lactamases). Use Avycaz (KPC, OXA-48), Recarbrio (KPC), Vabomere (KPC), or Fetroja (broad including metallo-β-lactamases) based on resistance pattern.
Penicillin allergy?
Caution in severe β-lactam allergy. ID team assesses risk vs. need; allergy testing may be considered.
Renal dosing?
Important — renal function changes during therapy (especially in critically ill patients). Frequent reassessment and dose adjustment needed.
Denied?
ID consult to assess alternatives. Hospital charity programs. PAP if uninsured.
Take Control of Your Medication Costs
If facing Zerbaxa cost, we can help coordinate manufacturer PAP and hospital billing. Check eligibility today.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.