XIAFLEX (collagenase clostridium histolyticum) Patient Assistance Program
Don’t let the high cost of brand collagenase therapy disrupt your Dupuytren’s or Peyronie’s treatment. We help eligible patients access Xiaflex (collagenase clostridium histolyticum) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey.
- Annual Re-certification And Refills Management
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Key Takeaways:
- Xiaflex (collagenase clostridium histolyticum) is FDA-approved for Dupuytren's contracture with a palpable cord and for Peyronie's disease in adult men with a palpable plaque and curvature deformity ≥30°. It is injected directly into the affected cord/plaque to enzymatically digest collagen — a nonsurgical alternative.
- Without assistance, Xiaflex costs commonly run approximately $3,500–$5,500 per injection vial.
- Through AffordMyPrescriptions, qualifying patients can access Xiaflex for a flat $69.95 per month.
- There is no generic Xiaflex. Alternative for Dupuytren's: needle aponeurotomy (much cheaper procedure but more recurrence) or surgical fasciectomy (more invasive but durable). For Peyronie's disease: pentoxifylline (off-label, generic, very cheap; modest benefit), intralesional verapamil (off-label, cheap), traction therapy, and surgical correction.
What Is Xiaflex Prescription Assistance Program?
Xiaflex PAP for Dupuytren’s/Peyronie’s patients.
Eligibility, hand surgeon/urology coordination.
AffordMyPrescriptions eliminates that burden. $69.95/month advocacy.
Pharmacy Price Comparison
- Without assistance, Xeomin costs roughly $400–$700 per 100-unit vial. A Patient Assistance Program is the meaningful path forward — if you qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens | ~$5,200 | Save substantially |
| CVS Pharmacy | ~$5,500 | Save substantially |
| Walmart | ~$3,700 | Save substantially |
| Costco | ~$3,600 | Save substantially |
Specialty Pharmacy | ~$4,000 | Save substantially |
*Just a heads-up — retail prices are estimates based on public data and vary by pharmacy. AffordMyPrescriptions Advocacy Service bypasses this by using drug manufacturer programs to secure your medication directly at no cost or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Xiaflex Prescription Program?
PAP at no cost. Needle aponeurotomy (Dupuytren’s) and off-label generic agents (Peyronie’s) cheaper alternatives.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Xiaflex:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Coupon cards expire and require constant renewal
Still $3,500–$5,500/vial per month even with the best discount
- Can’t be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
- Medication supplied directly through the assistance program
- We manage all paperwork, refills, and annual renewals
- If denied, we explore alternative savings on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Xiaflex assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Xiaflex Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured Or Underinsured And Cannot Afford Your Medication
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Not sure if you qualify? Our pre-qualification check is completely free. If we can’t help, you won’t be charged.
Understanding Xiaflex:
Xiaflex is bacterial collagenase injected directly into Dupuytren’s cords or Peyronie’s plaques to enzymatically digest the abnormal collagen — providing a nonsurgical alternative to fasciectomy (Dupuytren’s) or surgical correction (Peyronie’s).
How Xiaflex Works:
Dupuytren’s contracture involves progressive thickening and shortening of palmar fascia, producing flexion contractures of fingers. Peyronie’s disease involves fibrous plaque formation in tunica albuginea of penis, causing painful curvature.
Xiaflex contains two collagenases that hydrolyze collagen in the affected cord/plaque. Injection followed by 24–72 hour delay then finger extension manipulation (Dupuytren’s) or modeling/stretching (Peyronie’s). Multiple injections per cycle (up to 3 cycles for Peyronie’s, single or multiple cords for Dupuytren’s). Avoids surgical recovery.
Form and use:
Xiaflex injected by trained physician (hand surgeon for Dupuytren’s; urologist for Peyronie’s). Specific protocols for each indication. Patient performs penile modeling exercises post-injection for Peyronie’s.
Generic availability:
No generic. Alternatives — Dupuytren’s: needle aponeurotomy (~$500–$1,500 per finger, can be done in office; higher recurrence than surgery; cheaper than Xiaflex), surgical fasciectomy (more durable but more invasive). Peyronie’s: oral pentoxifylline (generic, $10–$30/month; modest benefit, often used long-term), intralesional verapamil (off-label, much cheaper than Xiaflex), traction devices, vacuum erection devices, surgery (penile plication or grafting for severe cases).
Warnings:
Xiaflex carries warnings for tendon rupture (Dupuytren’s — injection into tendons rather than cord can rupture; trained injector essential), nerve injury, corporal rupture/severe penile injury (Peyronie’s — including penile fracture; surgical repair may be needed), hypersensitivity reactions, swelling/bruising/pain at injection site, severe ecchymosis. Hematomas, lymphadenopathy, anaphylaxis (rare).
FAQ (Frequently Asked Questions)
Cost?
$3,500–$5,500/vial. PAP can help. Needle aponeurotomy or surgery cheaper alternatives for Dupuytren’s.
Dupuytren's: Xiaflex vs surgery vs needle aponeurotomy?
Xiaflex: nonsurgical, 1–2 injections per cord, recurrence ~50% at 5 years. Needle aponeurotomy: office procedure with needle to disrupt cord, higher recurrence than surgery. Open fasciectomy: most durable (lowest recurrence) but most invasive recovery. Choice depends on disease severity, hand function impact, surgical fitness, recurrence tolerance, cost.
Peyronie's: Xiaflex vs alternatives?
Xiaflex is the only FDA-approved injectable for Peyronie’s — modest curvature improvement (~30% reduction). Pentoxifylline (off-label, generic, very cheap) provides modest benefit; intralesional verapamil another off-label option. Surgery (plication or grafting) for severe cases or treatment failures.
Recurrence?
Dupuytren’s: ~50% recurrence at 5 years post-Xiaflex. Surgery has lower recurrence (~20% at 5 years). Peyronie’s: improvement is partial, not complete; some may need additional therapy or surgery.
Tendon rupture risk?
Major concern with Dupuytren’s injection if needle enters tendon rather than cord. Properly trained hand surgeon essential. Reported rates vary.
Corporal rupture in Peyronie's?
Serious adverse event — including penile fracture requiring surgical repair. Avoid sexual activity for ~4 weeks post-injection cycle. Follow modeling instructions carefully.
Denied?
Alternatives — needle aponeurotomy for Dupuytren’s (much cheaper office procedure), pentoxifylline for Peyronie’s. Manufacturer copay program for commercially insured.
Take Control of Your Medication Costs
If struggling with Xiaflex cost, we can help — or guide you to surgical alternatives or generic adjunct therapies. Check eligibility today.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.