LONSURF (trifluridine/tipiracil) Patient Assistance Program
Don’t let the high cost of brand specialty colorectal and gastric cancer therapy disrupt your treatment. We help eligible patients access Lonsurf (trifluridine/tipiracil) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey.
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
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Key Takeaways:
- Lonsurf (trifluridine/tipiracil) is FDA-approved for previously treated metastatic colorectal cancer (alone or in combination with bevacizumab) and for previously treated metastatic gastric or gastroesophageal junction adenocarcinoma. It is an oral nucleoside-analog/thymidine-phosphorylase-inhibitor combination.
- Without assistance, Lonsurf costs commonly run approximately $6,000–$7,500 per 28-day cycle.
- Through AffordMyPrescriptions, qualifying patients can access Lonsurf for a flat $69.95 per month — our advocacy team manages the entire enrollment, refills, and renewal process.
- There is no generic Lonsurf in the U.S. as of 2026. Other later-line colorectal cancer options include regorafenib (Stivarga, generic available — discussed elsewhere in this guide), fruquintinib (Fruzaqla), and various combinations with chemotherapy. Choice depends on prior therapy, biomarker profile, and tolerability.
What Is Lonsurf Prescription Assistance Program?
The Lonsurf Prescription Assistance Program is a manufacturer-sponsored initiative that provides Lonsurf at little or no medication cost to qualifying patients based on income and insurance status. The program is designed for previously treated metastatic colorectal or gastric cancer patients who are uninsured or underinsured, as well as Medicare Part D beneficiaries.
Navigating the program on your own means dealing with eligibility verification, oncology coordination, prior-authorization documentation, specialty pharmacy logistics, and renewal deadlines.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your enrollment, from initial application through ongoing refill coordination and re-certification.
Pharmacy Price Comparison
- Without assistance, Lonsurf costs roughly $6,000–$7,500 per 28-day cycle. A Patient Assistance Program is the meaningful path forward — if you qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens | ~$7,200 | Save ~$7,130/cycle |
| CVS Pharmacy | ~$7,500 | Save ~$7,430/cycle |
| Walmart | ~$6,300 | Save ~$6,230/cycle |
| Costco | ~$6,200 | Save ~$6,130/cycle |
Specialty Pharmacy | ~$6,500 | Save ~$6,430/cycle |
*Just a heads-up — retail prices are estimates based on public data and vary by pharmacy. AffordMyPrescriptions Advocacy Service bypasses this by using drug manufacturer programs to secure your medication directly at no cost or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Lonsurf Prescription Program?
The Patient Assistance Program is free to apply for and provides Lonsurf at no medication cost if approved. Our $69.95/month service covers full advocacy.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Lonsurf:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Coupon cards expire and require constant renewal
Still $6,000–$7,500/cycle per month even with the best discount
- Can’t be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
- Medication supplied directly through the assistance program
- We manage all paperwork, refills, and annual renewals
- If denied, we explore alternative savings on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Lonsurf assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Lonsurf Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Not sure if you qualify? Our pre-qualification check is completely free. If we can’t help, you won’t be charged.
Understanding Lonsurf:
Lonsurf (trifluridine/tipiracil) is an oral cytotoxic chemotherapy combination used to treat advanced colorectal and gastric cancers that have progressed on prior standard therapies. It is one of the few oral chemotherapy options for later-line management of these cancers.
LMX is liposomal lidocaine topical cream — over-the-counter local anesthetic for minor skin and anorectal pain. Liposomal formulation enhances skin penetration.
How Lonsurf Works:
Trifluridine is a cytotoxic thymidine analog that incorporates into DNA during replication, causing damage and cell death in rapidly dividing cancer cells. Because trifluridine alone is quickly broken down by an enzyme called thymidine phosphorylase in the liver and gastrointestinal tract, it is paired with tipiracil. Tipiracil acts as an inhibitor that blocks this breakdown, ensuring trifluridine safely reaches systemic circulation at effective therapeutic levels. This oral combination provides a modest overall survival benefit in advanced colorectal cancer, which can be further improved when paired with bevacizumab.
Form and use:
Lonsurf is an oral medication taken twice daily and must be consumed within one hour of finishing morning and evening meals. The standard dosage is based on the body’s surface area at 35 mg/m² per dose, rounded to the nearest 5 mg, up to a maximum of 80 mg per dose. It is administered on a strict schedule within a 28-day cycle: patients take the medication on days 1 through 5 and days 8 through 12, followed by 14 days off. Because of these specific timing requirements, it must always be taken with food.
Generic availability:
As of 2026, there is no generic version of Lonsurf available in the United States. Depending on prior therapies and biomarker profiles, other later-line treatment choices for metastatic colorectal cancer include regorafenib, which does have a generic version, and fruquintinib. For metastatic gastric cancer, alternative options include ramucirumab, nivolumab, and trastuzumab deruxtecan. Healthcare providers base the final choice of these therapies on a patient’s treatment history, specific biomarkers, and overall tolerability.
Warnings:
Lonsurf carries significant warnings for severe and potentially life-threatening myelosuppression, making complete blood count monitoring mandatory before and during every treatment cycle. This suppression commonly leads to side effects such as neutropenia, thrombocytopenia, and anemia, which may necessitate delays or reductions in the medication’s dose. The drug also carries a warning regarding embryo-fetal toxicity for pregnant individuals. Other common but less severe adverse events reported by patients include nausea, fatigue, vomiting, diarrhea, decreased appetite, abdominal pain, hair loss, and fever.
FAQ (Frequently Asked Questions)
How Much Does Lonsurf Cost Without Insurance?
Lonsurf costs approximately $6,000–$7,500 per 28-day cycle. Through AffordMyPrescriptions, qualifying patients receive Lonsurf at no medication cost — our $69.95 monthly fee covers full advocacy and program management.
How Does The 10-On/14-Off Dosing Schedule Work?
Lonsurf is taken twice daily on days 1–5 and days 8–12 of each 28-day cycle — then no Lonsurf for 14 days. So you take it for 5 days, take a 2-day break, take it for another 5 days, then take a 14-day break before starting the next cycle. The off period allows blood counts to recover. CBC is checked before each cycle and as needed during cycles.
Should Lonsurf Be Combined With Bevacizumab?
For metastatic colorectal cancer, recent data (SUNLIGHT trial) showed that Lonsurf + bevacizumab provides better overall survival than Lonsurf alone in third-line treatment. The combination is now FDA-approved and is generally preferred over Lonsurf monotherapy when bevacizumab can be safely added. Bevacizumab carries its own risks (bleeding, GI perforation, hypertension, proteinuria) and should be discussed with your oncologist.
What Side Effects Should I Watch For?
Most common: nausea, fatigue, vomiting, diarrhea, decreased appetite, abdominal pain, hair loss, fever. Important: signs of low blood counts (fever, mouth sores, severe fatigue, easy bruising/bleeding — call your oncologist for fever ≥100.4°F/38°C). Severe diarrhea can lead to dehydration — stay hydrated; use loperamide for diarrhea after consulting your oncologist. CBC is monitored regularly.
Is Lonsurf For Earlier-Line Treatment?
No. Lonsurf is approved for patients with metastatic colorectal or gastric cancer who have already received standard prior therapies (fluoropyrimidine, oxaliplatin, irinotecan-based therapy, and biologic therapy with anti-VEGF and/or anti-EGFR for colorectal). It is not first-line therapy. Earlier-line treatment uses standard chemotherapy combinations with or without targeted agents and immunotherapy.
Can I Get Lonsurf Through The PAP If I Have Medicare?
Yes. Medicare Part D beneficiaries can typically qualify, especially if you face specialty-tier copays. The manufacturer’s commercial copay savings program is reserved for commercially insured patients only — but the underlying PAP supports Medicare patients who meet income criteria.
What If My Application Is Denied?
If denied, we explore alternatives — switching to regorafenib (with generic available), fruquintinib (Fruzaqla), or re-challenge with prior chemotherapy regimens, the manufacturer’s copay program for commercially insured patients, or independent foundations such as the Colorectal Cancer Alliance, Fight CRC, Gastric Cancer Foundation, PAN Foundation, or HealthWell Foundation. If we cannot find a path, you won’t be charged our service fee.
Take Control of Your Medication Costs
If you are struggling with the high cost of Lonsurf, our team may be able to help you access assistance programs designed to make brand specialty oral chemotherapy affordable. Check your eligibility today.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.