Motegrity (prucalopride) Patient Assistance Program

Don’t let the high cost of brand chronic idiopathic constipation therapy disrupt your treatment. We help eligible patients access Motegrity (prucalopride) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.

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Key ​Takeaways:

What Is Motegrity Prescription Assistance Program?

Motegrity PAP for CIC.

Eligibility verification.

AffordMyPrescriptions eliminates that burden. $69.95/month advocacy.

Pharmacy Price Comparison

Pharmacy(With Coupon)PrIce (30-Day)*You Save W/ Us
Walgreens

~$720

Save ~$650/mo

CVS Pharmacy

~$750

Save ~$680/mo

Walmart 

~$540

Save ~$470/mo

Costco

~$520

Save ~$450/mo

OTC PEG (Miralax)

~$15/mo

Already low

*Just a heads-up — retail prices are estimates based on public data and vary by pharmacy. AffordMyPrescriptions Advocacy Service bypasses this by using drug manufacturer programs to secure your medication directly at no cost or retail price.

Our Pricing:

$69.95 Per month

1 Medications

$79.95 Per Month

2 Medications

$89.95 Per Month

3 Medications

$99.95 Per Month

4+ Medications

Why choose us For Your Motegrity Prescription Program?

OTC polyethylene glycol (Miralax) very cheap first-line CIC therapy. Generic lubiprostone cheaper Rx alternative.

Enroll

Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.

We Advocate

Our specialists help gather documentation, complete applications, and coordinate with program providers.

Receive Medication

Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.

Discount Coupons vs. Patient Assistance Programs

Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Motegrity:

Limitations of Coupons

  • Prices fluctuate — savings aren’t guaranteed month-to-month
  • Copay accumulators may prevent savings from counting toward deductible
  • Coupon cards expire and require constant renewal
  • Still $500–$750 per month even with the best discount

  • Can’t be used with Medicare, Medicaid, or government insurance

Advantages of PAP Through Us

  • Fixed $69.95/month — never changes regardless of retail price
  • No expiration — continuous access as long as you qualify
  • Medication supplied directly through the assistance program
  • We manage all paperwork, refills, and annual renewals
  • If denied, we explore alternative savings on your behalf

DO YOU QUALIFY?

Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Motegrity assistance.

Not sure if you qualify?  Our pre-qualification check is completely free. If we can’t help, you won’t be charged.

Understanding Motegrity:

Motegrity is highly selective 5-HT4 receptor agonist promoting colonic peristalsis. Modern safer alternative to tegaserod (withdrawn for CV concerns).

How Motegrity Works:

5-HT4 receptor activation stimulates colonic motility — peristaltic reflex, fluid secretion.

Prucalopride high selectivity for 5-HT4 (vs older agents) — avoids cardiovascular off-target effects that caused tegaserod withdrawal. Effective for CIC unresponsive to OTC laxatives.

Form and use:

Motegrity 2 mg once daily. Renal dose adjustment.

Generic availability:

No generic Motegrity. Other CIC options: linaclotide (Linzess), lubiprostone (Amitiza generic), plecanatide (Trulance). OTC: PEG (Miralax — first-line per guidelines, very cheap), fiber (psyllium), stimulant laxatives, magnesium-based.

Warnings:

Suicidal ideation (rare, monitor), diarrhea, headache, abdominal pain, nausea. Don’t use in severe inflammatory bowel disease, intestinal obstruction.

FAQ (Frequently Asked Questions)

Cost?

Motegrity $500–$750/month. OTC Miralax ~$15/month.

Yes — guidelines recommend OTC PEG (Miralax) as first-line CIC. Most patients respond. Rx agents (Motegrity, Linzess, Trulance) for inadequate response.

Different mechanisms. Motegrity 5-HT4 agonist (motility). Linzess/Trulance guanylate cyclase agonists (secretory). Choice based on response, side effects, insurance.

OTC PEG very cheap, generic lubiprostone, other options.

Take Control of Your Medication Costs

OTC PEG (Miralax) cheap first-line. Generic options for inadequate response. Check eligibility today.

Submit Enrollment Form

Start free by filling out a simple online form.

Receive Welcome Call

Our specialist will contact you for a quick welcome call.

We Manage The Process

Our team handles everything, so you can focus on your health.

Receive Welcome Call

We Manage The Process