Synvisc-One (hylan G-F 20) Patient Assistance Program
Don’t let the high cost of brand single-injection hyaluronic acid disrupt your knee osteoarthritis treatment. We help eligible patients access Synvisc-One (hylan G-F 20 single intra-articular knee injection) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
Key Takeaways:
- Synvisc-One (hylan G-F 20) is FDA-approved for treatment of pain in patients with osteoarthritis (OA) of the knee who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics. Single 6 mL intra-articular knee injection — same active ingredient as 3-injection series Synvisc, delivered in single-dose convenience.
- Without assistance, Synvisc-One costs commonly run approximately $1,500–$2,000 per single-injection treatment.
- Through AffordMyPrescriptions, qualifying patients can access Synvisc-One for a flat $69.95 per month.
- Same active ingredient as Synvisc (hylan G-F 20) — 3-injection weekly series. Other viscosupplementation products for knee OA: Hyalgan, Supartz, Euflexxa, Orthovisc, Gel-One, Monovisc, Genvisc — many brand and biosimilar/generic hyaluronic acid products. Standard knee OA management: weight loss, physical therapy, acetaminophen, generic NSAIDs (topical or oral), intra-articular corticosteroid injections (generic — cheaper). Viscosupplementation evidence is modest per updated OA management guidelines.
What is Synvisc-One Prescription Assistance Program?
The Synvisc-One Patient Assistance Program helps eligible patients access this single-injection knee viscosupplementation at little or no cost when meeting income, insurance, and clinical criteria.
At AffordMyPrescriptions, our Patient Advocates handle the entire Synvisc-One PAP enrollment for a flat $69.95 per month — so you never face a gap in Synvisc-One knee OA therapy.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your Synvisc-One enrollment — so you never face a gap in your knee osteoarthritis treatment.
Pharmacy Price Comparison
- Without assistance, Synvisc-One costs over a thousand dollars per injection. A Patient Assistance Program can offset costs if you qualify:
| PHARMACY | PRICE (30-DAY) WITH BEST COUPONS | YOU SAVE W/ US |
|---|---|---|
| Corticosteroid injection (alt) | ~$50/injection | Cheap generic alt IA |
| Orthopedic clinic | ~$1,700/dose | Save substantially |
| Rheumatology clinic | ~$1,900/dose | Save substantially |
| Hospital outpatient | ~$2,000/dose | Save substantially |
| 340B-eligible institution | ~$1,500/dose | Save substantially |
| Synvisc (3-injection series) | ~$1,800–$3,600 total | Same active drug, series |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. AffordMyPrescriptions Advocacy Service bypasses pharmacy pricing entirely by using the manufacturer’s assistance program to secure your Synvisc-One — independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Synvisc-One Prescription Program?
The Synvisc-One Patient Assistance Program is free to apply. Our $69.95 per month covers full advocacy. Single-injection convenience advantage vs 3-injection Synvisc series. Standard knee OA management prioritizes weight loss, physical therapy, and simple analgesics. Corticosteroid injections cheaper intra-articular alternative.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for Synvisc-One assistance.
We Advocate
Our specialists gather documentation, complete applications, and coordinate with your prescriber and the assistance program.
Receive Medication
Once approved, your Synvisc-One is delivered through the assistance program while we manage refills and annual renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Synvisc-One:
Limitations of Coupons
Prices fluctuate — savings aren’t guaranteed month-to-month
Copay accumulators may prevent savings from counting toward your deductible
Coupon cards expire and require constant renewal
Still $1,500–$2,000/dose per month even with the best discount
Cannot be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
Medication supplied directly through the assistance program
We manage all paperwork, refills, and annual renewals
Medicare Part D patients accepted
If denied, we explore alternative savings paths on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Synvisc-One assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Synvisc-One Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Synvisc-One:
Synvisc-One is a single 6 mL intra-articular knee injection of hylan G-F 20 (same active ingredient as 3-injection Synvisc series) — convenience advantage of single visit. For symptomatic knee osteoarthritis inadequately controlled with conservative measures.
How It Works:
Knee osteoarthritis (OA) is a common cause of pain and disability. Cartilage degeneration and synovial changes contribute to joint pain, stiffness, and functional limitation. Viscosupplementation aims to restore synovial fluid viscoelasticity. Hylan G-F 20 is a cross-linked hyaluronic acid product — higher molecular weight and viscosity than native hyaluronic acid. Synvisc-One delivers same active ingredient as 3-injection Synvisc series in a single larger dose (6 mL vs 3 mL × 3). Mechanism may include mechanical lubrication, anti-inflammatory effects. Effectiveness of viscosupplementation for knee OA is modest and debated per updated OA management guidelines. Single-injection convenience may improve adherence.
Form and Use:
Synvisc-One single 6 mL intra-articular knee injection. Ultrasound guidance or anatomic technique. Given at orthopedic, rheumatology, or specialty knee clinic. Can be repeated at ~6-month intervals if prior injection provided symptomatic benefit.
Generic Availability:
No generic Synvisc-One. Related product: Synvisc (hylan G-F 20 — same active ingredient, 3-injection weekly series). Other viscosupplementation products for knee OA: Hyalgan, Supartz, Euflexxa, Orthovisc, Gel-One, Monovisc, Genvisc — many brand and biosimilar/generic hyaluronic acid products with varying cost. Standard knee OA management: weight loss (evidence-based first-line), physical therapy, low-impact exercise, acetaminophen (generic — very cheap), NSAIDs — topical (diclofenac gel OTC or generic Rx) or oral generic (naproxen, ibuprofen, meloxicam, celecoxib generic), duloxetine (generic), intra-articular corticosteroid injections (generic — very cheap; effective for OA flares), platelet-rich plasma (variable evidence), total knee replacement for advanced disease. Arthritis Foundation resources.
Warnings:
Injection site pain, swelling, and effusion (post-injection reaction), avian protein sensitivity contraindication (Synvisc-One contains avian-derived hyaluronic acid; not for use in patients with hypersensitivity to avian proteins), infection risk with intra-articular procedure (rare — septic arthritis), pseudogout crystalline flare (rare), embryo-fetal considerations (systemic exposure minimal), hypersensitivity reactions. Other: injection site reactions, arthralgia. Single-injection may cause more prominent post-injection reaction than distributed 3-injection series in some patients.
FAQ (Frequently Asked Questions)
How much does Synvisc-One cost without insurance?
$1,500–$2,000 per single injection at orthopedic clinics. Comparable to full Synvisc 3-injection series total cost. Intra-articular corticosteroid injections cost ~$50 (generic) — significantly cheaper alternative for OA flares.
How is Synvisc-One different from Synvisc?
Same active ingredient (hylan G-F 20). Synvisc is 3-injection weekly series (3 mL × 3). Synvisc-One is single 6 mL injection — same total dose delivered in one visit. Convenience advantage of single visit. Similar effectiveness per FDA. Post-injection reactions may be more prominent with single larger injection.
How does Synvisc-One compare to intra-articular corticosteroid injection?
Corticosteroid injections (generic — very cheap) provide effective short-term symptomatic relief for OA flares. Repeated corticosteroid use limited by cartilage concerns. Viscosupplementation may provide longer duration of benefit (months) for select patients. Evidence for viscosupplementation is modest per updated OA guidelines. Corticosteroid often first choice for OA flares.
What is the evidence for viscosupplementation?
Evidence for hyaluronic acid viscosupplementation in knee OA is modest and debated. Updated OA management guidelines (ACR, OARSI, AAOS) provide conditional or limited recommendations. Some patients experience significant symptomatic benefit; others don’t. Weight loss, physical therapy, and simple analgesics remain first-line.
How long does Synvisc-One effect last?
Symptomatic benefit typically lasts several months (variable — some patients experience >6 months benefit, others less). Can be repeated at ~6-month intervals if prior injection provided benefit.
Take Control of Your Medication Costs
Single-injection viscosupplementation convenience for knee osteoarthritis. Our advocacy team is ready — $69.95 per month, or free if we cannot help.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.