Piasky (crovalimab-akkz) Patient Assistance Program
Don’t let the high cost of brand complement C5 inhibitor disrupt your paroxysmal nocturnal hemoglobinuria (PNH) treatment. We help eligible patients access Piasky (crovalimab-akkz SC injection) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
Key Takeaways:
- Piasky (crovalimab-akkz) is FDA-approved for treatment of paroxysmal nocturnal hemoglobinuria (PNH) in adults and pediatric patients (13 years and older) weighing at least 40 kg. Anti-C5 monoclonal antibody — recycles between plasma and endosome via a sweep mechanism, enabling every-4-week SC injection dosing.
- Without assistance, Piasky costs commonly run approximately $30,000+ per month.
- Through AffordMyPrescriptions, qualifying patients can access Piasky for a flat $69.95 per month.
- Other C5 inhibitors for PNH: Soliris (eculizumab — original C5 inhibitor, IV every 2 weeks after loading), Ultomiris (ravulizumab — long-acting IV or SC every 8 weeks). Alternative C3 inhibitor: Empaveli (pegcetacoplan — SC twice weekly). Fabhalta (iptacopan — oral factor B inhibitor for PNH, the first oral). Meningococcal vaccination is essential before starting a C5 inhibitor (encapsulated bacterial infection risk). Aplastic Anemia and MDS International Foundation. PNH support groups.
What is Piasky Prescription Assistance Program?
The Piasky Patient Assistance Program helps eligible patients access this SC C5 inhibitor at little or no cost when meeting income, insurance, and clinical criteria.
At AffordMyPrescriptions, our Patient Advocates handle the entire Piasky PAP enrollment for a flat $69.95 per month — so you never face a gap in Piasky PNH therapy.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your Piasky enrollment — so you never face a gap in your PNH treatment.
Pharmacy Price Comparison
- Without assistance, Piasky costs tens of thousands per month. A Patient Assistance Program can offset costs if you qualify:
| PHARMACY | PRICE (30-DAY) WITH BEST COUPONS | YOU SAVE W/ US |
|---|---|---|
| Fabhalta (alt oral) | ~$30,000/mo | Oral factor B alt |
| Specialty pharmacy | ~$32,000/mo | Save substantially |
| Hematology clinic | ~$33,000/mo | Save substantially |
| Hospital pharmacy | ~$35,000/mo | Save substantially |
| 340B-eligible institution | ~$28,000/mo | Save substantially |
| Ultomiris (alt long-acting C5) | ~$40,000/mo | Alt long-acting C5 |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. AffordMyPrescriptions Advocacy Service bypasses pharmacy pricing entirely by using the manufacturer’s assistance program to secure your Piasky — independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Piasky Prescription Program?
The Piasky Patient Assistance Program is free to apply. Our $69.95 per month covers full advocacy. PNH is an ultra-rare disease requiring specialty hematology care. Meningococcal vaccination is essential before starting any C5 inhibitor. Alternative C5 inhibitors and newer classes (C3 inhibitor, factor B inhibitor) provide additional options.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for Piasky assistance.
We Advocate
Our specialists gather documentation, complete applications, and coordinate with your prescriber and the assistance program.
Receive Medication
Once approved, your Piasky is delivered through the assistance program while we manage refills and annual renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Piasky:
Limitations of Coupons
Prices fluctuate — savings aren’t guaranteed month-to-month
Copay accumulators may prevent savings from counting toward your deductible
Coupon cards expire and require constant renewal
Still $28,000–$35,000 per month even with the best discount
Cannot be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
Medication supplied directly through the assistance program
We manage all paperwork, refills, and annual renewals
Medicare Part D patients accepted
If denied, we explore alternative savings paths on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Piasky assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Piasky Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Piasky:
Piasky is a newer anti-C5 monoclonal antibody with a novel sweep mechanism — recycling between plasma and endosome — enabling every-4-week SC injection dosing. A novel approach to C5 inhibition for paroxysmal nocturnal hemoglobinuria (PNH).
How It Works:
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder characterized by intravascular hemolysis, thrombosis, and cytopenias. Missing GPI-anchored complement regulatory proteins (CD55, CD59) render PNH red cells vulnerable to complement-mediated hemolysis. Historically it caused severe morbidity and mortality — complement inhibition transformed outcomes. Crovalimab is an anti-C5 monoclonal antibody with a unique sweep recycling mechanism — binding C5 in plasma at neutral pH and releasing it at endosomal acidic pH, allowing crovalimab to recycle. This extends the half-life and enables every-4-week SC dosing. It blocks terminal complement activation, preventing intravascular hemolysis — a similar clinical effect to eculizumab (Soliris) and ravulizumab (Ultomiris) but with SC monthly dosing convenience.
Form and Use:
Piasky SC injection. Loading regimen with initial doses. Maintenance: every 4 weeks SC. Requires meningococcal vaccination completed at least 2 weeks before starting (or antibiotic prophylaxis if urgent). Given at home or clinic.
Generic Availability:
No generic Piasky. Other C5 inhibitors for PNH: Soliris (eculizumab — original C5 inhibitor, IV every 2 weeks after loading; biosimilars in development), Ultomiris (ravulizumab — long-acting C5 inhibitor, IV every 8 weeks or SC every 8 weeks via delivery device). Newer classes: Empaveli (pegcetacoplan — C3 inhibitor, SC twice weekly), Fabhalta (iptacopan — factor B inhibitor, first oral PNH therapy). Meningococcal vaccination is essential before all C5 inhibitors (encapsulated bacterial infection risk). Aplastic Anemia and MDS International Foundation, PNH Support Group.
Warnings:
Meningococcal infection (BOXED WARNING — complement inhibition impairs immune defense against encapsulated bacteria; meningococcal vaccination essential at least 2 weeks before starting, or antibiotic prophylaxis if urgent; consider ongoing antibiotic prophylaxis; educate patients on infection symptoms — fever, headache, rash, mental status changes; carry a medical alert; immediate ED evaluation for any infection symptoms), other encapsulated bacterial infections (pneumococcal, H. influenzae b — vaccinate), infusion reactions (rare with SC), embryo-fetal considerations, drug transitions require careful timing. Other: injection site reactions, headache, upper respiratory infections. Hematology specialty care essential.
FAQ (Frequently Asked Questions)
How much does Piasky cost without insurance?
$28,000–$35,000 per month at specialty pharmacies. PNH therapy is among the most expensive in medicine — Patient Assistance Programs are essential.
How is Piasky different from Soliris (eculizumab) and Ultomiris (ravulizumab)?
All are anti-C5 monoclonal antibodies for PNH. Soliris: IV every 2 weeks after loading. Ultomiris: IV every 8 weeks or SC every 8 weeks. Piasky (novel sweep mechanism): SC every 4 weeks. Similar clinical efficacy — the differences are dosing frequency and route. Piasky’s SC every-4-weeks offers monthly convenience without the SC delivery-device requirement of Ultomiris SC.
How does Piasky compare to Empaveli and Fabhalta?
Different mechanisms. Piasky (C5 inhibitor): blocks terminal complement. Empaveli (pegcetacoplan — C3 inhibitor): blocks proximal complement upstream, with improved hemoglobin response in some patients but SC twice-weekly infusion. Fabhalta (iptacopan — factor B inhibitor): the first oral PNH therapy. Choice depends on individual response, adherence, and hematology guidance.
Why do I need meningococcal vaccination before Piasky?
Complement inhibition impairs immune defense against encapsulated bacteria — particularly Neisseria meningitidis. Meningococcal infection can be rapidly fatal. Vaccination is required at least 2 weeks before starting (or antibiotic prophylaxis if urgent). Ongoing antibiotic prophylaxis may also be recommended. Patients must recognize infection symptoms and seek immediate care.
What are Piasky side effects?
Injection site reactions, headache, upper respiratory infections. The major risk is meningococcal and other encapsulated bacterial infections — vaccination and infection vigilance are essential. Rare infusion reactions.
Take Control of Your Medication Costs
PNH therapy has been transformed by complement inhibition — accessible therapy is critical. Our advocacy team is ready — $69.95 per month, or free if we cannot help.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.