Ohtuvayre (ensifentrine) Patient Assistance Program
Don’t let the high cost of brand nebulized dual PDE3/PDE4 inhibitor disrupt your COPD treatment. We help eligible patients access Ohtuvayre (ensifentrine inhalation suspension) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
Key Takeaways:
- Ohtuvayre (ensifentrine) is FDA-approved (2024) for maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. First-in-class dual phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) inhibitor for COPD — bronchodilator + anti-inflammatory in one nebulized therapy. The first novel COPD mechanism in over a decade.
- Without assistance, Ohtuvayre costs commonly run approximately $2,400–$2,800 per month.
- Through AffordMyPrescriptions, qualifying patients can access Ohtuvayre for a flat $69.95 per month.
- Other nebulized COPD therapies: albuterol (generic short-acting rescue), levalbuterol (Xopenex generic), formoterol (Perforomist generic), Yupelri (revefenacin nebulized LAMA — brand). Standard inhaler-based COPD therapy: LAMAs (Spiriva HandiHaler generic, Incruse Ellipta), LAMA/LABA (Anoro Ellipta, Stiolto Respimat, Bevespi Aerosphere), triple therapy (Trelegy Ellipta, Breztri Aerosphere). Oral PDE4 inhibitor: roflumilast (Daliresp generic). Ohtuvayre may be added to standard inhaler therapy for further symptom improvement.
What is Ohtuvayre Prescription Assistance Program?
The Ohtuvayre Patient Assistance Program helps eligible patients access this dual PDE3/PDE4 inhibitor for COPD at little or no cost when meeting income, insurance, and clinical criteria. Free to apply but involves detailed applications, prescriber coordination, and renewal.
At AffordMyPrescriptions, our Patient Advocates handle the entire Ohtuvayre PAP enrollment for a flat $69.95 per month — so you never face a gap in Ohtuvayre COPD therapy.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your Ohtuvayre enrollment — so you never face a gap in your COPD maintenance treatment.
Pharmacy Price Comparison
- Without assistance, Ohtuvayre costs thousands per month. A Patient Assistance Program can offset costs if you qualify:
| PHARMACY | PRICE (30-DAY) WITH BEST COUPONS | YOU SAVE W/ US |
|---|---|---|
| Roflumilast generic (oral PDE4) | ~$150/mo | Oral PDE4 alt |
| Specialty pharmacy | ~$2,500/mo | Save substantially |
| Walgreens Specialty | ~$2,700/mo | Save substantially |
| CVS Specialty | ~$2,800/mo | Save substantially |
| 340B-eligible institution | ~$2,400/mo | Save substantially |
| Standard inhaler LAMA (alt) | ~$50/mo | Generic tiotropium alt |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. AffordMyPrescriptions Advocacy Service bypasses pharmacy pricing entirely by using the manufacturer’s assistance program to secure your Ohtuvayre — independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Ohtuvayre Prescription Program?
The Ohtuvayre Patient Assistance Program is free to apply. Our $69.95 per month covers full advocacy. Ohtuvayre is a novel COPD therapy — may be added to standard inhaler therapy for additional symptom improvement. Standard-of-care inhaled COPD therapy (LAMA, LAMA/LABA, triple therapy) generally remains the foundation.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for Ohtuvayre assistance.
We Advocate
Our specialists gather documentation, complete applications, and coordinate with your prescriber and the assistance program.
Receive Medication
Once approved, your Ohtuvayre is delivered through the assistance program while we manage refills and annual renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Ohtuvayre:
Limitations of Coupons
Prices fluctuate — savings aren’t guaranteed month-to-month
Copay accumulators may prevent savings from counting toward your deductible
Coupon cards expire and require constant renewal
Still $2,400–$2,800 per month even with the best discount
Cannot be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
Medication supplied directly through the assistance program
We manage all paperwork, refills, and annual renewals
Medicare Part D patients accepted
If denied, we explore alternative savings paths on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Ohtuvayre assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Ohtuvayre Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Ohtuvayre:
Ohtuvayre is the first-in-class dual PDE3/PDE4 inhibitor for COPD — a nebulized therapy with combined bronchodilator (PDE3 inhibition) and anti-inflammatory (PDE4 inhibition) effects. A novel mechanism complementary to standard inhaled bronchodilators and corticosteroids.
How It Works:
COPD involves both bronchoconstriction and airway inflammation. Standard therapy uses inhaled bronchodilators (SABAs, LABAs, LAMAs) and inhaled corticosteroids. The oral PDE4 inhibitor (roflumilast) provides anti-inflammatory benefit for severe COPD with chronic bronchitis. Novel therapy targets remained an unmet need. Ensifentrine is a dual PDE3 and PDE4 inhibitor. PDE3 inhibition causes airway smooth muscle relaxation (bronchodilation). PDE4 inhibition reduces inflammatory mediators. Combined mechanisms provide bronchodilation and anti-inflammatory effects in one nebulized therapy — an add-on to standard inhaler-based COPD therapy that established improved lung function and reduced exacerbations vs placebo in phase 3 trials.
Form and Use:
Ohtuvayre nebulized inhalation suspension. Twice daily via jet or vibrating mesh nebulizer. Individual dose ampules. Add-on to existing COPD inhaler therapy.
Generic Availability:
No generic Ohtuvayre. Other nebulized COPD therapies: albuterol (generic short-acting rescue), levalbuterol (Xopenex generic), formoterol (Perforomist generic — long-acting), Yupelri (revefenacin nebulized LAMA — brand). Standard inhaler-based COPD therapy: LAMAs (Spiriva HandiHaler generic, Incruse Ellipta, Tudorza Pressair), LAMA/LABA (Anoro Ellipta, Stiolto Respimat, Bevespi Aerosphere, Duaklir Pressair), triple therapy (Trelegy Ellipta, Breztri Aerosphere). ICS/LABA if applicable (Advair generic Wixela, Symbicort generic, Breo Ellipta, Dulera). Oral PDE4 inhibitor: roflumilast (Daliresp generic — for severe COPD with chronic bronchitis). COPD Foundation resources. Smoking cessation and pulmonary rehabilitation are essential components of COPD care.
Warnings:
Hypersensitivity reactions, embryo-fetal considerations, cardiovascular effects (theoretical from PDE3 inhibition — monitor), psychiatric effects (PDE4 inhibition — depression, mood changes possible), gastrointestinal effects (PDE4 inhibition — nausea, diarrhea, weight loss possible; less than oral roflumilast). Other: back pain, hypertension. A nebulizer is required — patients need access to a compatible device.
FAQ (Frequently Asked Questions)
How much does Ohtuvayre cost without insurance?
$2,400–$2,800 per month at specialty pharmacies. Standard inhaled COPD therapy (generic tiotropium LAMA, generic albuterol rescue) costs $50–$100/month. Ohtuvayre is an add-on for patients needing additional COPD control.
How is Ohtuvayre different from standard COPD inhaler therapy?
Ohtuvayre is a novel dual PDE3/PDE4 inhibitor with combined bronchodilator and anti-inflammatory effects in a nebulized therapy. Standard inhaled COPD therapy uses LAMAs, LABAs, and ICS (Anoro Ellipta, Trelegy Ellipta). Ohtuvayre is an add-on for additional symptom improvement — the first novel COPD mechanism in over a decade, complementary to standard inhaler therapy.
How is Ohtuvayre different from oral roflumilast (Daliresp)?
Both target PDE4. Roflumilast is an oral PDE4 inhibitor — significant psychiatric (depression) and GI side effects limit tolerability. Ohtuvayre is a nebulized dual PDE3/PDE4 inhibitor — reduced systemic exposure and improved tolerability vs oral roflumilast, and it adds PDE3 inhibition (bronchodilation).
Do I need to keep my current inhalers with Ohtuvayre?
Ohtuvayre is an add-on therapy — most patients continue standard inhaler-based COPD therapy (LAMA, LAMA/LABA, triple therapy). Discuss with your prescriber for an individualized regimen. Also continue your rescue inhaler (albuterol) for acute symptoms.
Do I need a special nebulizer for Ohtuvayre?
Ohtuvayre is compatible with jet nebulizers and vibrating mesh nebulizers. A nebulizer is required — many COPD patients may already have one for other nebulized therapy. Discuss device selection and technique with your prescriber and respiratory therapist.
Take Control of Your Medication Costs
Novel COPD mechanism therapy can improve symptoms for challenging patients. Our advocacy team is ready — $69.95 per month, or free if we cannot help.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.